Pedigree

[Click to Enlarge!] 

As you can see, John who is [homozygous dominant] diagnosed with CF, Jackie [heterozygous]a carrier, Cathy [homozygous recessive], and Frank [homozygous dominant] who is diagnosed with CF are my grandparents as well as Sarah's and Josh's. Natalie and Ethan are our parents, who are both carriers. 

Sarah was diagnosed with CF from inheriting two defective chromosome 7 with the gene responsible for CF [one from each parent] 

Sarah and her husband are allowed to have children, but it is taking them a very long time. Yet, they are not giving up! Sarah being diagnosed [homozygous dominant] and Jerry being a homozygous recessive know their child is going to be 100% not diagnosed with CF but still a heterozygous. 

Because our parents are both heterozygous, there was a 50% chance their children were going to be heterozygous, 25% homozygous recessive and 25% homozygous dominant. My brother Josh and I are both heterozygous, while Sarah fell into the 25% homozygous dominant category. If Josh and I both marry homozygous recessive indiviudals, we have a 50% chance our children will be heterozygous and a 50% chance of them being homozygous recessive. However, if we marry individuals who are diagnosed with CF, our children have 50% chance of being heterozygous and a 50% chance of them being homozygous dominant and inheriting CF. 

This is my last blog.. upsetting, I know. I hope you all enjoyed listening to my sister’s journey battling with Cystic Fibrosis in my point of view. Remember to keep her in your prayers. Thank you.